Hans-Reimer Rodewald

This study shows that myeloid differentiation in hematopoietic progenitors starts during S phase and is linked to chromatin changes and HOXA9 activity.

The paper tracks Flt3+ hematopoietic progenitors in vivo to show their lineage-restricted fates and long-lived output in immune cell compartments.

The paper traces individual PGC clones in mice to show early stochastic bottlenecks shape clonal contributions and reproductive success.

This study shows that mast cell deficiency does not impair immunological protection against sepsis, as Kit-mutant mice are as resistant as wild-type mice, with susceptibility instead due to intestinal dysbiosis.

The paper uses holistic genetic barcoding to map the lineage tree of tissue macrophage development in mice from gastrulation to adulthood, revealing local macrophage colonies that persist into adult organs.

Polytope enables high-resolution spatial fate-mapping by generating unique color codes through epitope barcoding in vivo.

The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.