Alessandro Greco

This study shows that myeloid differentiation in hematopoietic progenitors starts during S phase and is linked to chromatin changes and HOXA9 activity.

The paper uses fate-mapping, single-cell RNA-sequencing, and computational methods to show that major hematopoietic lineages diverge within HSCs, identifying a self-renewing HSC subpopulation and a direct thrombopoiesis pathway.

The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.

The paper uses matrix factorization to analyze molecular mechanisms behind the inverse comorbidity between Alzheimer’s disease and lung cancer, identifying new candidate factors and subtype-specific mechanisms.

This paper introduces a method to determine the optimal number of independent components for reproducible transcriptomic data analysis using ICA stability rankings.