A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding
Lei Wang, Jun Young Park, Fengming Liu, Kris M. Olesen, Shirui Hou, Jamy C. Peng, Jordan Infield, Anna C. Levesque, Yong‐Dong Wang, Hongjian Jin, Yiping Fan, Patrick J. Connelly, Shondra M. Pruett‐Miller, Miaofen G. Hu, Philip W. Hinds, Young-Goo Han
This study shows CDK6 promotes oRG expansion and neocortical folding in mice, ferrets, and human cerebral organoids, with its function independent of kinase activity and disrupted by microcephaly-causing mutations.
Proceedings of the National Academy of Sciences · Sep 12, 2022Peer-reviewedNeuroscience