Young-Goo Han

This study shows that BaP exposure of human ESCs before organoid generation causes premature neurogenesis and morphological defects, which can be reversed by AHR inhibition.

This study shows that Hedgehog signaling regulates mitotic spindle orientation in neural progenitors and iPSCs by affecting astral microtubules and transcriptional regulation of microtubule dynamics.

This study shows CDK6 promotes oRG expansion and neocortical folding in mice, ferrets, and human cerebral organoids, with its function independent of kinase activity and disrupted by microcephaly-causing mutations.

The paper shows bacterial PAMPs activate TLR2/6 on fetal NPCs, enhancing proliferation and altering brain development in mice.

This study shows that hedgehog signaling expands outer radial glia and intermediate progenitor cells in ferrets through two distinct phases of cellular mechanisms.