Author

Shirui Hou

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:non-human primate· 1

Frequent Co-Authors

Young-Goo HaniD· 3 shared Bryan Kuo· 2 shared Jun Young ParkiD· 2 shared Lei WangiD· 2 shared Anna C. Levesque· 1 shared Brent A. OrriD· 1 shared Chang‐Chih Wu· 1 shared Charles G. EberhartiD· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersDevelopmental Biology

Young-Goo HanORCID

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3 papers

Recent·Most cited

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding

Lei Wang, Jun Young Park, Fengming Liu, Kris M. Olesen, Shirui Hou, Jamy C. Peng, Jordan Infield, Anna C. Levesque, Yong‐Dong Wang, Hongjian Jin, Yiping Fan, Patrick J. Connelly, Shondra M. Pruett‐Miller, Miaofen G. Hu, Philip W. Hinds, Young-Goo Han

This study shows CDK6 promotes oRG expansion and neocortical folding in mice, ferrets, and human cerebral organoids, with its function independent of kinase activity and disrupted by microcephaly-causing mutations.

Proceedings of the National Academy of Sciences · Sep 12, 2022Peer-reviewedNeuroscience

Biphasic roles of hedgehog signaling in the production and self-renewal of outerradial glia in the ferret cerebral cortex

Shirui Hou, Wan‐Ling Ho, Lei Wang, Bryan Kuo, Jun Young Park, Young-Goo Han

This study shows that hedgehog signaling expands outer radial glia and intermediate progenitor cells in ferrets through two distinct phases of cellular mechanisms.

bioRxiv · Apr 12, 2021 · PreprintDevelopmental Biology

mTORC1-mediated inhibition of 4EBP1 is essential for Hedgehog (HH) signaling and can be targeted to suppress HH-driven medulloblastoma

Chang‐Chih Wu, Shirui Hou, Brent A. Orr, Bryan Kuo, Yong Ha Youn, Taren Ong, Fanny Roth, Charles G. Eberhart, Giles W Robinson, David J. Solecki, Makoto Mark Taketo, Richard J. Gilbertson, Martine F. Roussel, Young-Goo Han

Developmental Cell · Nov 2, 2017Peer-reviewedDevelopmental Biology