Lei Wang

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding

This study shows CDK6 promotes oRG expansion and neocortical folding in mice, ferrets, and human cerebral organoids, with its function independent of kinase activity and disrupted by microcephaly-causing mutations.

Biphasic roles of hedgehog signaling in the production and self-renewal of outerradial glia in the ferret cerebral cortex

This study shows that hedgehog signaling expands outer radial glia and intermediate progenitor cells in ferrets through two distinct phases of cellular mechanisms.