Anna Dorogin

A Broad-Spectrum Chemokine Inhibitor Prevents Preterm Labor in Mice by Suppressing Inflammation Induced by Intra-Amniotic Injection of Interleukin-1 alpha

This study shows that BSCI prevents preterm labor in mice by reducing inflammation and uterine gene expression changes caused by IL-1.

Temporal chromatin and transcriptome dynamics driven by JUND and progesterone receptor binding in the pregnant mouse myometrium

The paper identifies JUND and progesterone receptor binding dynamics in the pregnant mouse myometrium, linking chromatin accessibility changes to gene expression during pregnancy, labor, and postpartum.

JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium

This study identifies JUND's genome-wide role in regulating the myometrial transition from quiescence to contractility during labor.

SOX4 exerts contrasting regulatory effects on labor-associated gene promoters in myometrial cells

This study shows SOX4 regulates labor-associated gene promoters in myometrial cells through interactions with AP-1 factors, with varying effects on different promoters.

MYB and ELF3 differentially modulate labor-inducing gene expression in myometrial cells

The paper identifies MYB and ELF3 as transcription factors that differentially regulate labor-inducing gene expression in myometrial cells, with opposing effects on promoter activity.

The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice

The paper identifies epigenetic activation of contractility-driving genes in the mouse myometrium before labor onset, revealing early H3K27ac enrichment and transcriptional changes during active labor.