Luis E. Abatti

This paper shows that TP53 represses SOX2 in cancer cells, affecting cell identity and migration, with implications for metastasis in breast cancer.

The paper identifies an enhancer cluster that drives SOX2 overexpression in breast and lung cancer by altering chromatin accessibility and regulatory mechanisms.

The paper identifies epigenetic activation of contractility-driving genes in the mouse myometrium before labor onset, revealing early H3K27ac enrichment and transcriptional changes during active labor.

The paper shows that KLF4 protein stability, regulated by interactions with pluripotency factors, overrides transcriptional control in ES cells, and mutations affecting stability prevent differentiation.