Nawrah Khader

Temporal chromatin and transcriptome dynamics driven by JUND and progesterone receptor binding in the pregnant mouse myometrium

The paper identifies JUND and progesterone receptor binding dynamics in the pregnant mouse myometrium, linking chromatin accessibility changes to gene expression during pregnancy, labor, and postpartum.

JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium

This study identifies JUND's genome-wide role in regulating the myometrial transition from quiescence to contractility during labor.

THE CELLS ARE ALL-RIGHT: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells

The paper shows that Lefty1 and Lefty2 genes in mouse embryonic stem cells are regulated by separate enhancers despite being in the same TAD.

SOX4 exerts contrasting regulatory effects on labor-associated gene promoters in myometrial cells

This study shows SOX4 regulates labor-associated gene promoters in myometrial cells through interactions with AP-1 factors, with varying effects on different promoters.

MYB and ELF3 differentially modulate labor-inducing gene expression in myometrial cells

The paper identifies MYB and ELF3 as transcription factors that differentially regulate labor-inducing gene expression in myometrial cells, with opposing effects on promoter activity.

Transcriptional regulation and chromatin architecture maintenance are decoupled modular functions at the Sox2 locus

The paper shows that transcriptional control and chromatin architecture at the Sox2 locus are decoupled, with distinct regulatory mechanisms.

The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice

The paper identifies epigenetic activation of contractility-driving genes in the mouse myometrium before labor onset, revealing early H3K27ac enrichment and transcriptional changes during active labor.