Huayun Hou

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

The paper identifies TOP2B binding sites as mutational hotspots in cancer genomes, showing their role in structural variants and driver mutations in genes like TP53 and MYC.

This study evaluates how blood transcriptome profiling adds value to genome sequencing in diagnosing rare genetic disorders in a pediatric cohort.

The paper shows that the nuclear fragment of fat cadherin, generated by cleavage, regulates gene expression by interacting with Hippo pathway components and other factors.

The paper presents an updated reference genome for the naked mole-rat, identifying gene losses and gains linked to its unique physiological traits.

The paper analyzes hypothalamic gene expression in mice across puberty, identifying age- and sex-specific changes and their association with pubertal regulation.

The paper assesses the impact of rare canonical splice site variants on splicing using functional and in silico methods, finding that 24% of variants do not cause loss-of-function.

The paper develops DEET, a tool that reanalyzes differential gene expression data from multiple studies to help users compare their gene lists with existing results.

This study profiles gene and miRNA expression in mouse pituitaries across postnatal ages to identify sex-biased gene regulation and cell-type proportion differences during development.

scMappR assigns cell-type specificity scores to bulk RNA-seq DEGs using scRNA-seq data and deconvolution methods, showing accurate assignment in kidney regeneration analysis.

The paper demonstrates that extracellular vesicles from amniotic fluid stem cells can rescue impaired fetal lung development in experimental models.

The paper identifies epigenetic activation of contractility-driving genes in the mouse myometrium before labor onset, revealing early H3K27ac enrichment and transcriptional changes during active labor.