Oksana P. Shynlova

This study shows that BSCI prevents preterm labor in mice by reducing inflammation and uterine gene expression changes caused by IL-1.

The paper shows M1 macrophages transfer mitochondria to myocytes via tunneling nanotubes, enhancing ATP production and progesterone withdrawal, which initiates labor.

The paper identifies JUND and progesterone receptor binding dynamics in the pregnant mouse myometrium, linking chromatin accessibility changes to gene expression during pregnancy, labor, and postpartum.

This study identifies JUND's genome-wide role in regulating the myometrial transition from quiescence to contractility during labor.

This study shows SOX4 regulates labor-associated gene promoters in myometrial cells through interactions with AP-1 factors, with varying effects on different promoters.

The paper identifies MYB and ELF3 as transcription factors that differentially regulate labor-inducing gene expression in myometrial cells, with opposing effects on promoter activity.

The paper identifies epigenetic activation of contractility-driving genes in the mouse myometrium before labor onset, revealing early H3K27ac enrichment and transcriptional changes during active labor.

The paper identifies miRNA expression differences in whole blood and monocytes of women with spontaneous preterm labor compared to controls, linking them to immune pathways.