Chromatin structure and 3D architecture define differential functions of PU.1 cis regulatory elements in human blood cell lineages
Kevin Qiu, Duc Vu, Leran Wang, Anna K. Bookstaver, Thang N. Dinh, Adam N. Goldfarb, Daniel Geoffrey Tenen, Bon Q. Trinh
The paper identifies PU.1 cis-regulatory elements in human blood cell lineages and shows how chromatin structure and 3D architecture influence their function as enhancers or silencers.
bioRxiv · Jan 1, 2024 · PreprintGenetics