Competing forms of protein-protein association and DNA binding exhibited by BrxC from the BREX phage restriction system
Alex J Kaiser, Jennifer J. Readshaw, Lindsey Doyle, Maria Puiu, Abigail Kelly, Sydney F. McGuire, Julieta Peralta Acosta, Duc Vu, Andrew Nelson, Darren L. Smith, Lidia Araújo‐Bazán, Ernesto Arias‐Palomo, Yvette A. Luyten, Barry L. Stoddard, Tim R. Blower, Brett K. Kaiser
This study investigates the structural and functional properties of BrxC, a conserved AAA+ ATPase in the BREX phage restriction system, revealing its role in mediating competing protein associations and DNA binding that regulate host methylation and phage restriction.
bioRxiv · Apr 11, 2026 · PreprintBiochemistry