Bon Q. Trinh

The paper shows that oncogene-imposed dosage constraints can lead to mutations resembling tumor suppressor loss, which are essential in APL.

The paper identifies rare and common genetic variants associated with acute myeloid leukemia using whole-genome sequencing data from the All of Us Research Program.

This study identifies a PU.1/LOUP feed-forward regulatory loop that promotes monocyte/macrophage differentiation and innate immune functions through enhancer RNA-mediated mechanisms.

The paper identifies PU.1 cis-regulatory elements in human blood cell lineages and shows how chromatin structure and 3D architecture influence their function as enhancers or silencers.

This study shows that NAD affects DNA methylation and cell differentiation by promoting ADP-ribosylation of DNMT1, leading to CEBPA activation and myeloid differentiation.

The paper shows that cell cycle-specific long noncoding RNAs regulate the establishment and recycling of the acetylated histone H2A.Z epigenetic mark.

The paper identifies S-phase RNAs that anchor ORC1 to H2A.Z, enabling DNA replication initiation and revealing an RNA-mediated mechanism for replication origin formation.