Effector T Cells under Hypoxia have an Altered Transcriptome Similar to Tumor-Stressed T Cells Found in Non-Responsive Melanoma Patients
Mate Z Nagy, Lourdes Plaza-Rojas, Justin C. Boucher, Elena Kostenko, Anna L Austin, Ahmad A. Tarhini, Zhihua Chen, Dongliang Du, Awino Maureiq E. Ojwang’, Joshua Saul Davis, Alyssa Obermayer, Katarzyna Anna Rejniak, Timothy I. Shaw, Jose Alejandro Guevara-Patino
This study shows hypoxia alters T cell transcriptomes in melanoma, correlating with poor clinical outcomes in non-responders to immunotherapy.
Journal for ImmunoTherapy of Cancer · Feb 1, 2025Peer-reviewedImmunology