Author

Alyssa Obermayer

Moffitt Cancer CenterORCID 0000-0002-7333-973XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Timothy I. ShawiD· 3 shared Ahmad A. TarhiniiD· 2 shared Dorina AvramiD· 2 shared Jose Ramon Conejo-GarciaiD· 2 shared Zhihua CheniD· 2 shared Τόμας ΖελένκαiD· 2 shared Alex Alfaro· 1 shared Amod SarnaikiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

Timothy I. ShawORCID

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3 papers

Recent·Most cited

BCL11B targeting in tumor CD8+ T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicity

Leonardo Silvane, Τόμας Ζελένκα, Divya Priyanka Talada, Valeriu Bogdan Cismasiu, Shamima Islam, Raghwendra P. Singh, Zefanias Ngove, Sayan Chakraborty, MacLean S. Hall, Jamie L. Blauvelt, Erika Adriana Eksioglu, Soraya Zorro Manrique, Joseph Johnson, Alyssa Obermayer, Alex Alfaro, , Dorina Avram

This paper shows that reducing BCL11B in CD8+ T cells enhances anti-tumor response by preventing exhaustion and boosting stemness and cytotoxicity.

bioRxiv · Aug 7, 2026 · PreprintImmunology

Effector T Cells under Hypoxia have an Altered Transcriptome Similar to Tumor-Stressed T Cells Found in Non-Responsive Melanoma Patients

Mate Z Nagy, Lourdes Plaza-Rojas, Justin C. Boucher, Elena Kostenko, Anna L Austin, Ahmad A. Tarhini, Zhihua Chen, Dongliang Du, Awino Maureiq E. Ojwang’, Joshua Saul Davis, Alyssa Obermayer, Katarzyna Anna Rejniak, Timothy I. Shaw, Jose Alejandro Guevara-Patino

This study shows hypoxia alters T cell transcriptomes in melanoma, correlating with poor clinical outcomes in non-responders to immunotherapy.

Journal for ImmunoTherapy of Cancer · Feb 1, 2025Peer-reviewedImmunology

BERLIN: Basic Explorer for single-cell RNAseq analysis and cell Lineage Determination.

Gabrielle Nobles, Alyssa Obermayer, Ching Yao Yang, Τόμας Ζελένκα, Thanh N Nugyen, Zhihua Chen, Jose Ramon Conejo-Garcia, Dorina Avram, Xiaoqing Yu, Y. Ann Chen, Timothy I. Shaw

BERLIN reanalyzes single-cell RNAseq data to identify cell types and lineages, showing accurate results in acute myeloid leukemia and tumor-reactive lymphocytes.

bioRxiv · Jul 13, 2023 · PreprintBioinformatics