Timothy I. Shaw

This paper shows that reducing BCL11B in CD8+ T cells enhances anti-tumor response by preventing exhaustion and boosting stemness and cytotoxicity.

This study shows hypoxia alters T cell transcriptomes in melanoma, correlating with poor clinical outcomes in non-responders to immunotherapy.

BERLIN reanalyzes single-cell RNAseq data to identify cell types and lineages, showing accurate results in acute myeloid leukemia and tumor-reactive lymphocytes.

The paper introduces a method to identify differential super enhancers by considering internal dynamics, revealing novel structural alterations with distinct regulatory impacts and improving identification compared to existing methods.

Adapterama II introduces a flexible and cost-effective method for amplicon sequencing on Illumina platforms using fusion primers and quadruple indexing.