Verónica Brito

Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene

The paper develops URSA, a method to quantify DNA repair activity at the CAG repeat tract in HD, showing it correlates with somatic instability and can be measured rapidly in blood cells.

Targeted 3'-end RNA sequencing uncovers cryptic polyadenylation in Huntington's disease linked to somatic instability and CAG repeat purity

This paper introduces 3TRS, a targeted RNA sequencing method to quantify HTT transcripts in HD models, revealing cryptic polyadenylation linked to somatic instability and CAG repeat purity.

Transcriptional and synaptic regulation of NMDA glutamate receptor-mediated hippocampal plasticity and memory

The paper identifies CREB/CRTC1-regulated gene programs that link synaptic activity to transcriptional control of NMDA receptor-mediated plasticity and memory in hippocampal neurons.

m6A RNA modification of mHtt intron 1 regulates the generation of Htt1a in Huntington's Disease

This study investigates how m6A RNA modifications in Htt intron 1 regulate the production of the pathogenic Htt1a transcript in Huntington's Disease.

Hippocampal Egr1-dependent neuronal ensemblesnegatively regulate motor learning

The paper shows that Egr1-dependent hippocampal neuronal ensembles limit motor learning in mice.