Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages
Rosanna C. T. Wright, Simon C. Lovell, Anna Richmond, Christian Harrison, Eleri A. Ashworth, Aras Kadioglu, Jo Fothergill, Ville‐Petri Friman, Edze Rients Westra, Michael A. Brockhurst
The paper shows CRISPR immunity in Pseudomonas aeruginosa varies in fitness benefit against virulent phages, depending on the likelihood of evolving receptor-based resistance through spontaneous mutations.
bioRxiv · Oct 5, 2025 · PreprintMicrobiology