Michael A. Brockhurst

The paper shows that removing genetic barriers from Pseudomonas aeruginosa hosts increases the diversity of recoverable phages, leading to the isolation of 69 new phages from clinical isolates.

The paper reports a near telomere-to-telomere genome assembly of Micractinium conductrix, enabling genomic studies of endosymbiosis and biotechnological applications.

The paper develops a method to screen plasmid host range using auxotrophic donors, finding that donor identity affects conjugation success in environmental soil bacteria.

The paper shows that adaptation to free-living conditions in algal endosymbionts leads to loss of host benefits, driven by metabolic trade-offs, with nitrogen availability as a key factor.

The paper investigates how resistance to T6SS toxins evolves, finding toxin-specific resistance mechanisms and trade-offs in E. coli.

This study analyzes antibiotic resistance emergence in Pseudomonas aeruginosa during treatment, finding that pre-existing resistance and ecological dynamics drive resistance development.

The paper analyzes defence system interactions in Pseudomonas aeruginosa genomes to understand their role in shaping accessory genome dynamics and ecological patterns.

This study shows that endosymbiotic algae evolve traits specialized for intracellular niches, reducing their fitness in extracellular environments, thereby stabilizing endosymbiosis through evolutionary entrapment.

This study shows that plasmid-dependent phage treatment removes pathogenic bacteria and antibiotic resistance plasmids from chicken gut microbiomes without disrupting overall microbiome composition.

This study shows that multidrug resistance plasmids face a trade-off between phage resistance and conjugative ability, which affects their evolutionary response to plasmid-dependent phages.

The paper shows CRISPR immunity in Pseudomonas aeruginosa varies in fitness benefit against virulent phages, depending on the likelihood of evolving receptor-based resistance through spontaneous mutations.

This paper identifies two point mutations in a two-component system that confer vancomycin resistance in C. difficile, revealing a synergistic pathway for resistance in epidemic strains.

The paper shows that host inflammatory environments constrain the loss of quorum sensing in Pseudomonas aeruginosa by linking it to oxidative stress and amino acid availability.

This study shows that chromosomal mutations in Escherichia coli enhance resistance to carbapenems when combined with plasmid-encoded OXA-48, despite not compensating for plasmid fitness costs.

This study shows that multiple toxins in T6SS limit resistance evolution in bacteria, similar to combination therapies in medicine.

The paper demonstrates the use of an engineered environmental plasmid to enable terephthalate degradation in soil by transferring synthetic genes to resident bacteria.

This study compares the ecological effects of compensatory mutations on plasmids and chromosomes, finding that chromosomal mutations are more effective in reducing plasmid fitness costs and promoting plasmid spread.

This study uses comparative genomics of Arsenophonus to show that endosymbionts initially expand their genomes through horizontal gene transfer and loss of defense systems, followed by genome reduction.

This study identifies an immune-like glycan-sensing/processing network in Paramecium bursaria that regulates its algal endosymbionts through horizontal gene transfers.

The paper analyzes the genomic diversity of Pseudomonas aeruginosa in bronchiectasis, revealing distinct evolutionary patterns compared to cystic fibrosis and highlighting antimicrobial resistance mechanisms.