Edze Rients Westra

The paper shows that diversity in restriction-modification systems is maintained through trade-offs between defense strength and horizontal transferability, and provides collective protection against phages.

This study shows that loss of type I restriction-modification methyltransferases in Pseudomonas aeruginosa increases fluoroquinolone persistence through enhanced SOS response and slower growth.

The paper defines the mechanism of the MANTIS defence system in Pseudomonas aeruginosa, showing how dual ATPases couple self-modification to non-self restriction through adenine hemimethylation and cleavage.

The paper shows that removing genetic barriers from Pseudomonas aeruginosa hosts increases the diversity of recoverable phages, leading to the isolation of 69 new phages from clinical isolates.

This study profiles the infant gut virome using dual methods and finds associations with eczema and wheeze.

The paper analyzes defence system interactions in Pseudomonas aeruginosa genomes to understand their role in shaping accessory genome dynamics and ecological patterns.

The paper shows CRISPR immunity in Pseudomonas aeruginosa varies in fitness benefit against virulent phages, depending on the likelihood of evolving receptor-based resistance through spontaneous mutations.

The paper examines defence system abundances in microbial communities, finding environmental and viral density effects on their prevalence.

The paper tests a synthetic CRISPR-Cas system in Pseudomonas aeruginosa against 13 phages and finds nutrient-dependent protection efficacy.

This study shows spatial structure can either promote or hinder the spread of cooperative anti-CRISPR phages, depending on host and phage efficacy.

The paper investigates eco-evolutionary feedbacks between restriction-modification systems and antimicrobial resistance gene acquisition using modeling and genome analysis.

This study tracks changes in gut plasmid populations and antibiotic resistance during and after antibiotic therapy in a single patient with ESBL-carrying E. coli.

The paper examines how Restriction-Modification systems affect plasmid conjugation in E. coli, finding that plasmids often encode anti-RM strategies, reducing the effectiveness of RM systems as a barrier.