RasGRP1 promotes efficient intestinal tuft cell differentiation
Lauren A. Shechtman, Philippe Depeille, Eric Smith, Hong-Erh Liang, Tammie S. Y. Tam, Annabelle Duflock, Victor S. Cortez, Claire E. O’Leary, Alan Shen, Wouter Bos, Gabriela K. Fragiadakis, Alexis J. Combes, Hugo González, Richard M. Locksley, Jeroen P. Roose
This study identifies RasGRP1 as a regulator of tuft cell differentiation in the intestine, showing it restricts progenitor proliferation and enhances IL-13-driven responses.
bioRxiv · Oct 2, 2026 · PreprintCell Biology