Richard M. Locksley

This study identifies RasGRP1 as a regulator of tuft cell differentiation in the intestine, showing it restricts progenitor proliferation and enhances IL-13-driven responses.

The paper shows that mite-induced migratory CD103+ skin ILC2s enter the lung, become resident, and alter lung immunity by changing immune response trajectories.

This study identifies circulating inflammatory ILC2s as a biomarker for gastric cancer progression, showing their association with disease severity and potential for early detection.

The paper shows that telocytes relay signals from enteroendocrine cells to ILC2s, amplifying the tuft cell circuit in response to feeding.

This study shows that IL-25 induces memory ILC2s in the small intestine that provide long-term protection against barrier pathogens.

The paper identifies five discrete metabolic domains in the mouse and human small intestine using transcriptional signatures and machine learning, showing how diet influences domain properties.