Author

Victor S. Cortez

University of California, San FranciscoORCID 0000-0002-9353-0777Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Claire E. O’LearyiD· 2 shared Hong-Erh LiangiD· 2 shared Richard M. LocksleyiD· 2 shared Alan Shen· 1 shared Alexis J. CombesiD· 1 shared Andrew SchroederiD· 1 shared Annabelle Duflock· 1 shared Dario BoffelliiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Claire E. O’LearyORCID

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2 papers

Recent·Most cited

RasGRP1 promotes efficient intestinal tuft cell differentiation

Lauren A. Shechtman, Philippe Depeille, Eric Smith, Hong-Erh Liang, Tammie S. Y. Tam, Annabelle Duflock, Victor S. Cortez, Claire E. O’Leary, Alan Shen, Wouter Bos, Gabriela K. Fragiadakis, Alexis J. Combes, Hugo González, Richard M. Locksley, Jeroen P. Roose

This study identifies RasGRP1 as a regulator of tuft cell differentiation in the intestine, showing it restricts progenitor proliferation and enhances IL-13-driven responses.

bioRxiv · Oct 2, 2026 · PreprintCell Biology

IL-25-induced memory ILC2s mediate long-term small intestinal adaptation

Victor S. Cortez, Sara Viragova, Satoshi Koga, Meizi Liu, Claire E. O’Leary, Roberto R. Ricardo-González, Andrew Schroeder, Nathan P. Kochhar, Dedeepya Vaka, Dario Boffelli, Ophir D. Klein, Michael Diamond, Hong-Erh Liang, Richard M. Locksley

This study shows that IL-25 induces memory ILC2s in the small intestine that provide long-term protection against barrier pathogens.

Cell · Sep 5, 2025Peer-reviewedImmunology