PSMε controls skin commensal CD8+ T cell activation
William S. Owens, Kevin Lenzi, Wendy Geng, Annalisa Hurd, Jessie Liu, Caleb Staudinger, Brittany M. Berdy, Cameron Genxuan Lian, Namrata D. Udeshi, Steven A. Carr, Christopher D. Johnston, Jonathan Livny, Yiyin Erin Chen
This study identifies PSMε as a key molecular component that drives CD8+ T cell activation by commensal bacteria, offering a mechanism for immunotherapy without live bacterial colonization.
bioRxiv · Aug 4, 2026 · PreprintImmunology