Author

Brittany M. Berdy

Broad InstituteORCID 0000-0002-8593-0762Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Jonathan LivnyiD· 3 shared Abigail E. Rose· 2 shared Alexandra C. Schrimpe‐RutledgeiD· 2 shared JOHN A. JUN. MCLEANiD· 2 shared Karsten ZengleriD· 2 shared Luisella SpigaiD· 2 shared M. Wade CalcuttiD· 2 shared Madison Langford-Butler· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Jonathan LivnyORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PSMε controls skin commensal CD8+ T cell activation

William S. Owens, Kevin Lenzi, Wendy Geng, Annalisa Hurd, Jessie Liu, Caleb Staudinger, Brittany M. Berdy, Cameron Genxuan Lian, Namrata D. Udeshi, Steven A. Carr, Christopher D. Johnston, Jonathan Livny, Yiyin Erin Chen

This study identifies PSMε as a key molecular component that drives CD8+ T cell activation by commensal bacteria, offering a mechanism for immunotherapy without live bacterial colonization.

bioRxiv · Aug 4, 2026 · PreprintImmunology

Rational engineering of facultative anaerobiosis enables commensal survival in the oxygenated gut

Abigail E. Rose, Madison Langford-Butler, Luisella Spiga, Daniel W. Bak, Maxwell Neal, Muen Shen, M. Wade Calcutt, Ryan T. Fansler, Sanjay Kumar Rohaun, Mohamad Feron, Alexandra C. Schrimpe‐Rutledge, Brittany M. Berdy, Simona G. Codreanu, Stacy D. Sherrod, Owen F. Hale, , Wenhan Zhu

This study engineers obligate anaerobic bacteria to tolerate oxygen, improving their survival in the gut.

bioRxiv · Jun 6, 2026 · PreprintMicrobiology

An Anaerobic Pathogen Rewires Host Metabolism to Fuel Oxidative Growth in the Inflamed Gut

Luisella Spiga, Ryan T. Fansler, Yifan Wu, Alexandra Grote, Madison Langford-Butler, Asia K. Miller, M J Neal, Owen F. Hale, Deepanshu Singla, M. Wade Calcutt, Abigail E. Rose, Madeline M. Bresson, Alexandra C. Schrimpe‐Rutledge, Brittany M. Berdy, Simona G. Codreanu, , Wenhan Zhu

This study shows how ETBF reprograms host metabolism to create an oxidative niche that supports its growth in the inflamed gut.

Cell · Apr 30, 2026Peer-reviewedMicrobiology

Phosphorothioate DNA modification by BREX Type 4 systems in the human gut microbiome

Yifeng Yuan, Michael S. DeMott, Shane R. Byrne, Katia Flores, Mathilde Poyet, Mathieu Groussin, Brittany M. Berdy, J. Rusine-Bahunde, Catherine Girard, Jenni Lehtimäki, Audax Z. P. Mabulla, Ivan Emil Mwikarago, Yvonne Ayerki Nartey, Le Thanh Tu Nguyen, Charles Asabamaka Onyekwere, , Peter C. Dedon

The paper identifies new phosphorothioate DNA modification systems in the human gut microbiome using genomic and mass spectrometric analysis.

Nature Communications · Jan 22, 2026Peer-reviewedMicrobiology