Namrata D. Udeshi

The paper develops scalable cell-free protein synthesis platforms to generate single-cell RNA-sequencing data on immune cell responses to cytokines and other signals, enabling functional discovery and drug target prioritization.

This paper designs a new proximity labeling enzyme, FlexID, using computational methods to improve spatial precision and versatility for mapping protein interactions and proteomes.

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

This study identifies PSMε as a key molecular component that drives CD8+ T cell activation by commensal bacteria, offering a mechanism for immunotherapy without live bacterial colonization.

This study uses in-situ glial cell-surface proteomics in Drosophila to identify DIP-β as a pro-longevity factor regulated by glial cells.

This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.

This paper identifies a PTP activity-independent mechanism by which SHP2 promotes RAS/ERK activation through direct binding to SOS1.

The paper introduces endocytome profiling to map cell-surface protein dynamics in developing olfactory receptor neurons, revealing how endocytosis regulates axon pruning and targeting.

The paper shows UV exposure causes misfolded melanosomal proteins to aggregate, contributing to skin pigmentation disorders and melanocyte dysfunction.

This study identifies HIF2-driven PTHrP as a cause of cachexia and hypercalcemia in kidney cancer and shows that HIF2 inhibitors can alleviate these symptoms.

This study compares two surface proteomics methods for analyzing CSPs in low-input and cryopreserved samples, showing high reproducibility and identifying over 700 CSPs.

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

This study identifies DNA hypomethylation, not DNA damage, as the primary mechanism of azacytidine and decitabine anti-cancer activity, linking it to chromatin regulators like USP48.

This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.

This study identifies coagulation and immune factors secreted by Drosophila gut tumors that contribute to cachexia via NFκB and JNK pathways.

This study identifies the intracellular signaling pathway of teneurins in synaptic partner matching using Drosophila models.

This study presents an automated single-cell proteomics workflow that identifies over 4,000 proteins per cell and detects key regulatory proteins in LPS-perturbed THP-1 cells.

The paper identifies Pp1-87B as a regulator of core PCP signaling by modulating Van Gogh subcellular localization and dephosphorylation in Drosophila wings.

This paper introduces LOV-Turbo, a light-regulated proximity labeling tool that enhances spatial and temporal control of proteomic mapping in living cells.

This study identifies Acj6 as a transcription factor that controls dendrite targeting in Drosophila PNs by regulating combinatorial expression of cell-surface proteins.

This study identifies KLHL40 as a negative regulator of ER-Golgi trafficking through ubiquitylation, revealing its role in skeletal muscle development and disease.

The paper profiles cell-surface proteomes in Drosophila olfactory neurons across development, identifying new regulators of neural circuit assembly.

This study shows glucocorticoids expand immature CFU-E cells in peripheral blood but not cord blood, with p57Kip2 playing a key role in this effect.