ApoE isoforms establish distinct antioxidant trajectories across the aging brain
Sarah J Shemtov, Mafalda Cacciottolo, Amy Christensen, Boyang Li, Amin Haghani, Michelle C. Rice, Herbert Anson, Claire S. Chung, Whitaker Cohn, Hongqiao Zhang, Wendy J. Mack, Annie Hiniker, Changhan Lee, Todd E. Morgan, Elizabeth Head, , Max A. Thorwald
This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.
bioRxiv · Nov 9, 2026 · PreprintEvolutionary Biology