Boyang Li

ApoE isoforms establish distinct antioxidant trajectories across the aging brain

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease

This study shows that TOMM40 suppression leads to cholesterol imbalance and AD-like molecular and behavioral changes in mice and human neurons.

Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

This study identifies microglia as key contributors to senescence in Alzheimer's disease, linking cholesterol dysregulation to senescence pathologies through transcriptomic analysis of multiple datasets.

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

This study uses multi-trait analysis to identify novel genetic loci for smoking behaviors by leveraging alcohol use disorder GWAS data from the Million Veteran Program.

Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations

The paper identifies genetic variants in RASA1 and EPHB4 associated with vein of Galen malformations through exome analysis and single-cell transcriptomics.

Quantifying concordant genetic effects of de novo mutations on multiple disorders

This paper introduces EncoreDNM, a statistical framework to quantify shared genetic effects of de novo mutations between disorders using exome-wide summary data, revealing abundant pairwise enrichment correlations.

Local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits

This study introduces SUPERGNOVA, a framework for estimating local genetic correlations, and identifies 150 trait pairs with significant local genetic correlations, including autism spectrum disorder and cognitive performance.

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

This study identifies 29 risk variants for problematic alcohol use through a large meta-analysis and explores its genetic relationships with other traits.

Functions for Cdc42p BEM Adaptors in Regulating a Differentiation-Type MAP Kinase Pathway

The paper investigates how Cdc42p adaptors regulate the fMAPK pathway in yeast, showing distinct activation kinetics and sequential interactions between Bem4p and Bem1p.

A statistical framework for cross-tissue transcriptome-wide association analysis

The paper introduces a statistical framework for cross-tissue transcriptome-wide association analysis, improving gene-trait association detection and identifying novel genes related to late-onset Alzheimer's disease.

Characterization and identification of long non-coding RNAs based on feature relationship

This study characterizes long non-coding RNAs (lncRNAs) by analyzing feature relationships and introduces LGC, an algorithm that accurately identifies lncRNAs across species without prior knowledge.

A powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statistics

This paper introduces a method to estimate annotation-stratified genetic covariance between traits using GWAS summary statistics, identifying significant genetic covariances among 50 complex traits.

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease

The paper introduces GenoSkyline-Plus, a framework for tissue-specific functional annotation of the human genome, showing its utility in identifying immune-related DNA elements linked to late-onset Alzheimer’s disease.