Author

Changhan Lee

University of Southern CaliforniaORCID 0000-0002-4375-7391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Michelle C. RiceiD· 2 shared Amin HaghaniiD· 1 shared Amy ChristenseniD· 1 shared Annie Hiniker· 1 shared Ariana Chen· 1 shared Bérénice Anath BenayouniD· 1 shared Boyang LiiD· 1 shared Caleb Finch· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersEvolutionary Biology

Michelle C. RiceORCID

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Author profile →

2 papers

Recent·Most cited

ApoE isoforms establish distinct antioxidant trajectories across the aging brain

Sarah J Shemtov, Mafalda Cacciottolo, Amy Christensen, Boyang Li, Amin Haghani, Michelle C. Rice, Herbert Anson, Claire S. Chung, Whitaker Cohn, Hongqiao Zhang, Wendy J. Mack, Annie Hiniker, Changhan Lee, Todd E. Morgan, Elizabeth Head, , Max A. Thorwald

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

bioRxiv · Nov 9, 2026 · PreprintEvolutionary Biology

MOTS-c Coordinates Inter-Organellar Proteostasis for Adaptation to Chronic Metabolic Stress

Conscience P. Bwiza, Ella Schwab, Lily Xia, Ariana Chen, Elijah Song, Sabrina Lin, E Sle Kim, Yui Hashiyada, JM Son, Michelle C. Rice, Jessica Kim, Sara Martins, Eun Hee Koh, Bérénice Anath Benayoun, Changhan Lee

This study identifies MOTS-c as a mitochondrial-derived peptide that coordinates inter-organellar proteostasis to enable adaptation to chronic metabolic stress.

bioRxiv · Jun 23, 2026 · PreprintCell Biology