Decoding the Variant-to-Function Relationship for LIPA, a Risk Locus for CAD
Fang Li, Elise D. Flynn, Philip Ha, Mazal N. Zebak, Haoxiang M. Cheng, Chenyi Xue, Jianting Shi, Xun Wu, Ziyi Wang, Yujiao Meng, Jian Guo Cui, Yizhou Zhu, Annie Rozenblyum, Jeana Chun, Antonio Hernández‐Ono, , Hanrui Zhang
The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.
bioRxiv · Nov 12, 2022 · PreprintGenomics