Ali Javaheri

Impaired proteostasis is an early feature of the diabetic heart in humans and mice

This study shows that impaired proteostasis is an early feature of diabetic cardiomyopathy in humans and mice, with intermittent fasting offering protective effects.

Label free multimodal optical imaging of metabolic heterogeneity and correlation in aging by integrating SRS, MPF, FLIM, and SHG

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation and inflammation in MASLD

This study shows that inducing TFEB in Kupffer cells reduces cell death, lipid accumulation, and inflammation in MASLD.

Phosphorylation of CRYAB Induces a Condensatopathy to Worsen Post-Myocardial Infarction Left Ventricular Remodeling.

This study shows that phosphorylation of CRYAB leads to condensate formation and worsens heart failure after myocardial infarction.

Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation

This study shows that Sirt3 is induced during glucose deprivation and supports synaptic transmission by enhancing mitochondrial function and synaptic vesicle recycling.

Decoding the Variant-to-Function Relationship for LIPA, a Risk Locus for CAD

The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.