Babak Razani

Impaired proteostasis is an early feature of the diabetic heart in humans and mice

This study shows that impaired proteostasis is an early feature of diabetic cardiomyopathy in humans and mice, with intermittent fasting offering protective effects.

Activated fatty acid synthesis pathway in macrophages propagates pathogenic fibroblast expansion after myocardial infarction

This study shows that macrophage fatty acid synthesis promotes fibroblast expansion and fibrosis after myocardial infarction.

Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation and inflammation in MASLD

This study shows that inducing TFEB in Kupffer cells reduces cell death, lipid accumulation, and inflammation in MASLD.

Phosphorylation of CRYAB Induces a Condensatopathy to Worsen Post-Myocardial Infarction Left Ventricular Remodeling.

This study shows that phosphorylation of CRYAB leads to condensate formation and worsens heart failure after myocardial infarction.

metGWAS 1.0: An R workflow for network-driven over-representation analysis between independent metabolomic and meta-genome wide association studies

metGWAS 1.0 statically evaluates independent metabolomics and GWAS studies to identify novel metabolite-gene associations using hypergeometric testing.

Decoding the Variant-to-Function Relationship for LIPA, a Risk Locus for CAD

The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.

SVEP1, a novel human coronary artery disease locus, promotes atherosclerosis

This study identifies SVEP1 as a novel coronary artery disease locus that promotes atherosclerosis by affecting vascular smooth muscle cell function and signaling pathways.