Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state
Mary C. Rominger, Siobhan O’Brien, Saksham Gupta, Sitapriya Moorthi, Maria V. McSharry, Shriya Kamlapurkar, Amy R. Lowe, Annie Waldum, April Lo, Fujiko F. Duke, Feinan Wu, Mark B. Headley, Elizabeth A. Cromwell, Raisa A. Glabman, Amanda L. Koehne, Alice H. Berger
This paper develops a mouse model of RIT1M90I-driven lung cancer and identifies YAP/TEAD as a therapeutic target for RIT1-mutant lung cancer.
Cell Reports · Sep 25, 2025Peer-reviewedCancer Biology