Author

Mark B. Headley

Fred Hutch Cancer CenterORCID 0000-0002-0924-9326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alice H. BergeriD· 1 shared Amanda L. KoehneiD· 1 shared Amy R. Lowe· 1 shared Andrew J. SnyderiD· 1 shared Andrew OberstiD· 1 shared Annelise G. SnyderiD· 1 shared Annie Waldum· 1 shared April LoiD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

Alice H. BergerORCID

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4 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 15, 2025

NKTR-255, a polymer-conjugated IL-15, synergizes with CAR-T cell therapy to activate endogenous anti-tumor immunity and improve tumor control

W. Sam Nutt, Mitchell G. Kluesner, Emma Bingham…·Shivani Srivastava

This study shows that combining NKTR-255 with CAR-T therapy enhances tumor control by boosting CAR-T function and endogenous anti-tumor immunity in solid tumors.

1 citation

mouseexperimental assay

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ImmunologybioRxivPreprintSep 30, 2025

Ontogeny and functional potential of founding dendritic cells in the developing lung

Radika Soysa, Saajidah Abideen, Victor Zepeda Reyes, Mark B. Headley

The paper identifies two distinct dendritic cell subsets in fetal and newborn mouse lungs, showing unique ontogeny and functional characteristics compared to adult DCs.

1 citation

mousescRNA-seq

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Cancer BiologyCell ReportsPeer-reviewedSep 25, 2025

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

Mary C. Rominger, Siobhan O’Brien, Saksham Gupta…·Alice H. Berger

This paper develops a mouse model of RIT1M90I-driven lung cancer and identifies YAP/TEAD as a therapeutic target for RIT1-mutant lung cancer.

1 citation

mouseexperimental assay

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Cancer BiologyCommunications BiologyPeer-reviewedJul 29, 2025

Apoptotic cells promote circulating tumor cell survival and metastasis

Cassidy E. Hagan, Valerie M. Sheehan, Charles M. Rezanka…·Andrew Oberst

This study shows apoptotic cells enhance metastasis by promoting CTC survival through coagulation and platelet clot formation.

8 citations

mouseproteomics

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