Author

Amy R. Lowe

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alice H. BergeriD· 2 shared Siobhan O’BrieniD· 2 shared Amanda L. KoehneiD· 1 shared Annie Waldum· 1 shared April LoiD· 1 shared Elizabeth A. CromwelliD· 1 shared Feinan WuiD· 1 shared Fujiko F. Duke· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenetics

Alice H. BergerORCID

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2 papers

Recent·Most cited

Transcriptional adaptation influences buffering among essential paralog gene families

Siobhan O’Brien, Marissa Fujimoto, Amy R. Lowe, Alice H. Berger

The paper investigates transcriptional adaptation in paralog gene families using Perturb-seq, finding six paralog pairs show adaptation and identifying mechanisms like nonsense-mediated decay and nuclear import.

bioRxiv · Sep 29, 2026 · PreprintGenetics

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

Mary C. Rominger, Siobhan O’Brien, Saksham Gupta, Sitapriya Moorthi, Maria V. McSharry, Shriya Kamlapurkar, Amy R. Lowe, Annie Waldum, April Lo, Fujiko F. Duke, Feinan Wu, Mark B. Headley, Elizabeth A. Cromwell, Raisa A. Glabman, Amanda L. Koehne, Alice H. Berger

This paper develops a mouse model of RIT1M90I-driven lung cancer and identifies YAP/TEAD as a therapeutic target for RIT1-mutant lung cancer.

Cell Reports · Sep 25, 2025Peer-reviewedCancer Biology