Author

Amanda L. Koehne

Fred Hutch Cancer CenterORCID 0000-0002-1397-6964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

Martin PrliciD· 2 shared Alexis K TaberiD· 1 shared Alice H. BergeriD· 1 shared Amy R. Lowe· 1 shared Annie Waldum· 1 shared April LoiD· 1 shared Brianna R. Traxinger· 1 shared Chelsea Schmitz· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Martin PrlicORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Regulatory T cells restrain cytotoxic and bystander CD8 T cells without compromising antigen-driven memory in mucosal tissue

Irene Cruz Talavera, Jessica B. Graham, Jessica L. Swarts, Brianna R. Traxinger, M Quinn Peters, Lakshmi Warrier, Amanda L. Koehne, Tanvi Arkatkar, Keith R. Jerome, Martin Prlic, Jennifer M. Lund

The paper investigates how regulatory T cells control cytotoxic and bystander CD8 T cell activity in mucosal tissues without affecting antigen-driven memory responses.

bioRxiv · Jul 8, 2026 · PreprintImmunology

Human lung γδ T cells maintain functionality during inflammatory lung disease

Alexis K Taber, Marie Frutoso, Nicole B. Potchen, Amanda L. Koehne, Chelsea Schmitz, Eric D. Morrell, Martin Prlic, Shelton W. Wright

This study examines the functionality of human lung γδ T cells in inflammatory lung disease and finds they maintain polyfunctional cytokine expression despite environmental changes.

bioRxiv · Apr 27, 2026 · PreprintImmunology

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

Mary C. Rominger, Siobhan O’Brien, Saksham Gupta, Sitapriya Moorthi, Maria V. McSharry, Shriya Kamlapurkar, Amy R. Lowe, Annie Waldum, April Lo, Fujiko F. Duke, Feinan Wu, Mark B. Headley, Elizabeth A. Cromwell, Raisa A. Glabman, Amanda L. Koehne, Alice H. Berger

This paper develops a mouse model of RIT1M90I-driven lung cancer and identifies YAP/TEAD as a therapeutic target for RIT1-mutant lung cancer.

Cell Reports · Sep 25, 2025Peer-reviewedCancer Biology