Activity profiling of deubiquitinating inhibitors-bound to SARS-CoV-2 papain like protease with antiviral efficacy in murine infection model
Shweta Choudhary, Sanketkumar Nehul, Santhosh Kambaiah Nagaraj, Rohan Narayan, Shalja Verma, Swati Sharma, Annu Kumari, Ruchi Rani, Ankita Saha, Debabrata Sircar, Abinaya Kaliappan, Shashank Tripathi, Gaurav Kumar Sharma, Pravindra Kumar, Shailly Tomar
This study identifies DUB inhibitors that target SARS-CoV-2 PLpro, inhibiting its proteolytic activity and restoring immune responses in a mouse model.
bioRxiv · Nov 11, 2022 · PreprintMicrobiology