Gaurav Kumar Sharma

Disruption of molecular interactions between G3BP1 stress granule host protein and nucleocapsid (NTD-N) protein impedes SARS-CoV-2 virus replication

This study identifies a new molecular interaction between G3BP1 and SARS-CoV-2 N protein and shows small molecules disrupt this interaction, reducing viral replication.

Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS-COV-2 targeting virus-specific enzymes

This study evaluates the antiviral and anti-inflammatory effects of triterpenoids against SARS-CoV-2 by targeting viral proteases and host immune pathways.

Revealing and evaluation of antivirals targeting multiple druggable sites of RdRp complex in SARS-CoV-2

This study identifies antivirals targeting multiple sites of SARS-CoV-2 RdRp complex through in-silico screening, SPR validation, and cell-based assays, showing potent antiviral effects.

Chimeric chikungunya virus-like particles with surface exposed SARS-CoV-2 RBD elicits potent immunogenic responses in mice.

This study develops a bivalent chimeric virus-like particle vaccine displaying CHIKV and SARS-CoV-2 RBD antigens, showing potent immunogenicity in mice.

Activity profiling of deubiquitinating inhibitors-bound to SARS-CoV-2 papain like protease with antiviral efficacy in murine infection model

This study identifies DUB inhibitors that target SARS-CoV-2 PLpro, inhibiting its proteolytic activity and restoring immune responses in a mouse model.

Mechanistic and thermodynamic characterization of antivirals targeting druggable pocket of SARS-CoV-2 nucleocapsid

This study identifies antivirals targeting the NTD of SARS-CoV-2 N protein using structure-based drug repurposing and shows their effectiveness in inhibiting viral replication.