Ruchi Rani

This study compares the pathogenicity and transmissibility of bovine- and human-derived H5N1 viruses in mouse and hamster models, finding high pathogenicity but limited transmissibility.

This study shows that deleting ORF6 from SARS-CoV-2 reduces virulence and pathogenicity in cats, with decreased immune suppression and reduced viral replication.

This study examines H5N1 influenza virus pathogenesis and transmission in cats, showing genotype-dependent differences in disease severity, shedding, and transmissibility.

This study identifies efavirenz's anti-CHIKV activity and shows it inhibits viral replication by targeting minus-sense RNA synthesis, suggesting its repurposing for antiviral therapy.

This study identifies two N-terminal deletions in SARS-CoV-2 nsp1 that reduce innate immune evasion but do not impact viral virulence.

This study identifies antivirals targeting multiple sites of SARS-CoV-2 RdRp complex through in-silico screening, SPR validation, and cell-based assays, showing potent antiviral effects.

This study identifies DUB inhibitors that target SARS-CoV-2 PLpro, inhibiting its proteolytic activity and restoring immune responses in a mouse model.