Shalja Verma

Structural insights into PFAS-β-lactoglobulin binding mechanism mediating PFAS toxicity

This study reveals how β-lactoglobulin binds PFAS compounds through structural analysis and molecular dynamics, showing hydrophobic and electrostatic interactions that stabilize the binding.

Mechanistic insights into the inhibition of dengue virus NS5 methyltransferase by herbacetin

This study identifies herbacetin as an inhibitor of dengue virus NS5 methyltransferase, revealing its binding mechanism and potential as a scaffold for antiviral drugs.

Unveiling the PET plastics degradation potential of the thermostable EstS1 esterase through integrated biochemical, structural, and morphological analyses

This study demonstrates EstS1 esterase's ability to degrade PET plastic and its intermediate BHET, supported by kinetic, structural, and morphological analyses.

Unveiling Mechanistic and Structural Insights of EstS1 Esterase: A Potent Broad-Spectrum Phthalate Diester Degrading Enzyme

This study characterizes the structural and mechanistic properties of EstS1 esterase, revealing its role in degrading phthalate diesters through a bi-bi ping-pong mechanism and covalent substrate binding.

Activity profiling of deubiquitinating inhibitors-bound to SARS-CoV-2 papain like protease with antiviral efficacy in murine infection model

This study identifies DUB inhibitors that target SARS-CoV-2 PLpro, inhibiting its proteolytic activity and restoring immune responses in a mouse model.