Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Annu Nagar, Ryuji Yanase, Mohammad Zeeshan, David J. P. Ferguson, Steven Abel, Sarah L. Pashley, Akancha Mishra, Anthonius Anayochukwu Eze, Edward Rea, Declan Brady, Andrew R. Bottrill, Sue Vaughan, Karine G. Le Roch, David S. Guttery, Anthony A. Holder, , Rita Tewari
This study identifies ARK1 as a critical regulator of mitosis in Plasmodium, forming a non-canonical chromosomal passenger complex with divergent INCENPs, and highlights its potential as an antimalarial target.
Nature Communications · Feb 26, 2026Peer-reviewedMicrobiology