Declan Brady

This study identifies SFA1's role in coordinating cytoskeletal organisation, apical polarity, and cell replication during Plasmodium sexual development, showing its necessity for parasite transmission.

This study uses electron tomography to investigate basal body dynamics during microgamete formation and fertilization in Plasmodium, revealing novel structural features and their role in gamete fusion.

This study identifies Plasmodium NEK4 as a key regulator that couples meiotic initiation with zygote morphogenesis in malaria parasites.

This study shows that Plasmodium Protein Kinase 2 is essential for the ookinete to oocyst transition and sporozoite development in the mosquito, affecting parasite transmission.

The paper identifies GAPM2 as an IMC component in Plasmodium species and reveals its heterotrimeric complex structure and functional role in the glideosome.

This study identifies ARK1 as a critical regulator of mitosis in Plasmodium, forming a non-canonical chromosomal passenger complex with divergent INCENPs, and highlights its potential as an antimalarial target.

This study shows Apicortin is localized to the apical conoid body of Plasmodium berghei during transmission but is not essential for parasite development or transmission.

This study identifies three Plasmodium protein kinases involved in regulating MTOC, kinetochore, and axoneme organisation during male gametogenesis, revealing their substrates and morphological effects.

This study identifies the SUN1-ALLAN complex as critical for coordinating nuclear envelope remodeling and bipartite MTOC segregation during rapid mitosis in Plasmodium male gametogenesis.

This study identifies NEK1's role in organizing the MTOC and ensuring kinetochore attachment during rapid mitosis in Plasmodium male gamete formation.

This study examines changes in genome organization during the transmission stages of Plasmodium parasites and finds that three-dimensional genome structure is linked to transcriptional activity of gene families involved in pathogenesis and immune evasion.