Anthony A. Holder

Plasmodium rootlet SFA1 coordinates cell replication, apical polarity and cytoskeletal organisation during sexual development

This study identifies SFA1's role in coordinating cytoskeletal organisation, apical polarity, and cell replication during Plasmodium sexual development, showing its necessity for parasite transmission.

A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis

This study identifies Plasmodium NEK4 as a key regulator that couples meiotic initiation with zygote morphogenesis in malaria parasites.

Plasmodium Protein Kinase 2 is required for ookinete to oocyst transition, and parasite transmission by the mosquito.

This study shows that Plasmodium Protein Kinase 2 is essential for the ookinete to oocyst transition and sporozoite development in the mosquito, affecting parasite transmission.

Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex

This study identifies ARK1 as a critical regulator of mitosis in Plasmodium, forming a non-canonical chromosomal passenger complex with divergent INCENPs, and highlights its potential as an antimalarial target.

Apicortin defines the Plasmodium apical conoid body during transmission but is dispensable for the parasite life cycle

This study shows Apicortin is localized to the apical conoid body of Plasmodium berghei during transmission but is not essential for parasite development or transmission.

Divergent Plasmodium protein kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis

This study identifies three Plasmodium protein kinases involved in regulating MTOC, kinetochore, and axoneme organisation during male gametogenesis, revealing their substrates and morphological effects.

A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium

This study identifies the SUN1-ALLAN complex as critical for coordinating nuclear envelope remodeling and bipartite MTOC segregation during rapid mitosis in Plasmodium male gametogenesis.

Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation

This study identifies NEK1's role in organizing the MTOC and ensuring kinetochore attachment during rapid mitosis in Plasmodium male gamete formation.

PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages

This study identifies PfAP2-MRP as a master regulator controlling parasite growth, chromatin structure, and var gene expression during malaria parasite blood stages.