Trans-presentation of IL-15 by IL15Rα attenuates tumor immune surveillance and is dispensable for IL-15-dependent tumor growth control
Fjolla Rexhepi, Sara Ali Akbari, Mohammad Moradzad, Saeed Khodayari, Akhil Shukla, Élodie Demontier, Jean‐François Lucier, Anny Armas Cayarga, Hugues Allard‐Chamard, Subburaj Ilangumaran, Sheela Ramanathan
This study shows IL-15R restrains tumor immune surveillance but is dispensable for IL-15-dependent tumor growth control, while IL-15 has minimal role in spontaneous tumor development.
Cancers · Aug 4, 2026Peer-reviewedImmunology