Sheela Ramanathan

A strong-to-weak interaction shift during microbiome succession is coupled to colonizer-dependent antimicrobial resistance

This study tracks microbiome succession in mice, showing a shift from strong to weak interactions linked to colonizer-dependent antimicrobial resistance.

Trans-presentation of IL-15 by IL15Rα attenuates tumor immune surveillance and is dispensable for IL-15-dependent tumor growth control

This study shows IL-15R restrains tumor immune surveillance but is dispensable for IL-15-dependent tumor growth control, while IL-15 has minimal role in spontaneous tumor development.

SOCS1 expression in prostate epithelial cells is essential for tissue homeostasis and tumor suppression

This study shows that SOCS1 in prostate epithelial cells is crucial for tissue homeostasis and tumor suppression by controlling proliferation, inflammation, and DNA damage response.

NLRC5 expression in tumor cells is critical to activate adaptive and innate antitumor immune responses

This study shows that NLRC5 expression in tumor cells enhances MHC-I and promotes antitumor immunity by activating immune cells and shaping the tumor microenvironment.

Essential role of NLRC5 in cancer immune surveillance and cancer immunoediting

This study shows NLRC5 is essential for tumor immune surveillance and immunoediting, as its deficiency leads to increased tumor growth and reduced immune control.

Molecular Insights into Long COVID: Plasma Proteomics Reveals Oxidative Stress, Coagulation Cascade Activation, and Glycolytic Imbalance

This study uses plasma proteomics to identify molecular changes in long COVID, revealing oxidative stress, coagulation activation, and glycolytic imbalance.

SILAC proteomics implicates the ubiquitin conjugating enzyme UBE2D in SOCS1-mediated downmodulation of the MET receptor in hepatocytes

The paper uses SILAC proteomics to show SOCS1 modulates 181 proteins in Hepa1-6 cells, with UBE2D being a key target involved in MET receptor regulation.