Structural basis of p62/SQSTM1 helical filaments, their presence in p62 bodies and role in cargo recognition in the cell
Arjen J. Jakobi, Stefan T. Huber, Simon Arnold Mortensen, Sebastian Wolfgang Schultz, Anthimi Palara, Tanja Kuhm, Birendra Kumar Shrestha, Trond Lamark, Wim J. H. Hagen, Matthias Wilmanns, Terje Johansen, Andreas Brech, Carsten Sachse
This study determines the structural basis of p62/SQSTM1 PB1 domain filaments, their role in phase-separated p62 bodies, and their importance in cargo recognition and lysosomal targeting.
Nature Communications · Jan 23, 2020Peer-reviewedMolecular Biology