Sebastian Wolfgang Schultz

Time-resolved functional genomics using deep learning reveals a global hierarchical control of autophagy

This study uses deep learning and time-resolved imaging to map the genetic network controlling autophagy dynamics, revealing a hierarchical control mechanism and new regulatory aspects.

SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics

This study identifies SNX10 as a negative regulator of piecemeal mitophagy and mitochondrial bioenergetics, showing its role in modulating mitochondrial homeostasis and cell survival.

Structural basis of p62/SQSTM1 helical filaments, their presence in p62 bodies and role in cargo recognition in the cell

This study determines the structural basis of p62/SQSTM1 PB1 domain filaments, their role in phase-separated p62 bodies, and their importance in cargo recognition and lysosomal targeting.