DNA replication in primary hepatocytes without the six-subunit ORC
Róża K. Przanowska, Yuechuan Chen, Takayuki-Okano Uchida, Etsuko Shibata, Xiaoxiao Hao, Isaac Segura Rueda, Kate N. Jensen, Piotr Przanowski, Anthony J. Trimboli, Yoshiyuki Shibata, Gustavo W. Leone, Anindya Dutta
This study shows that primary hepatocytes can replicate DNA without ORC2, similar to cancer cell lines, by loading MCM2-7 complexes.
eLife · Apr 30, 2025Peer-reviewedGenetics