Piotr Przanowski

Critical role of cell competition in gliomagenesis

This study identifies cell competition as a key driver of gliomagenesis by showing that pre-malignant OPCs outcompete wildtype cells, and inhibiting this process reduces tumor growth.

DNA replication in primary hepatocytes without the six-subunit ORC

This study shows that primary hepatocytes can replicate DNA without ORC2, similar to cancer cell lines, by loading MCM2-7 complexes.

Patient-derived response estimates from zero-passage organoids of luminal breast cancer

This study develops zero-passage organoids from luminal breast cancer patient samples to test genetic and pharmacologic perturbations, finding variable hormone responsiveness and complex interactions with sulforaphane and NQO1 knockout.

Kinetic networks identify Twist2 as a key regulatory node in adipogenesis

The paper identifies Twist2 as a key regulatory node in adipogenesis using kinetic networks derived from ATAC-seq and PRO-seq data.

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

The paper identifies distinct structural domains in the MUNC lncRNA that regulate different promyogenic genes through cis and trans mechanisms.

miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro

The paper shows that the miR-206 family is not essential for myogenesis in vitro but affects mitochondrial function and muscle performance in vivo.